Sequential chemotherapy and radiotherapy for squamous cell esophageal carcinoma
| Autor: | Steven Lunzer, Robert G. Wadleigh, Steven H. Krasnow, Eugene B. Davis, Mohammed A. Hussain, Daya Sharma |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Urology Phases of clinical research Antineoplastic Combined Chemotherapy Protocols Carcinoma medicine Humans Esophagus Aged Cisplatin Chemotherapy Esophageal disease business.industry Middle Aged medicine.disease Combined Modality Therapy Radiation therapy medicine.anatomical_structure Oncology Epidermoid carcinoma Carcinoma Squamous Cell Fluorouracil Nuclear medicine business medicine.drug |
| Zdroj: | American journal of clinical oncology. 20(2) |
| ISSN: | 0277-3732 |
| Popis: | A Phase II study of sequential chemotherapy with 5-fluorouracil and cisplatin followed by radiotherapy was initiated to see whether the use of two therapies sequentially could have an effect on response rate. Thirteen patients with advanced squamous cell carcinoma of the esophagus were treated with 1,000 mg/m 2 /day 5-fluorouracil days 1-5 continuously and 100 mg/m 2 cisplatin on day 1. An average of four cycles (range, one to nine) were given every 28 days; 11 patients received more than three cycles. The radiation consisted of 60 Gy over 6-8 weeks. There was only one (8%) complete response (CR) and 11 (85%) partial responses (PRs). Restaging after radiation revealed no conversion of PR to CR. Median survival was 39 weeks (range, 6-208+). Chemotherapy alone or its use sequentially with radiotherapy is inadequate, and newer approaches are needed to to improve survival. |
| Databáze: | OpenAIRE |
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