Outer nuclear membrane fusion of adjacent nuclei in varicella-zoster virus-induced syncytia
| Autor: | Xiumin Huang, Jianghui Ye, Ningshao Xia, Jian Liu, Wei Wang, Dequan Pan, Lianwei Yang, Wenkun Fu, Tong Cheng, Hua Zhu, Linli Cai |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Herpesvirus 3 Human Nuclear Envelope viruses Context (language use) Biology medicine.disease_cause Giant Cells Virus Cell Line Cell Fusion 03 medical and health sciences Multinucleate Virology medicine Humans Nuclear membrane Cytopathic effect Skin Syncytium Varicella zoster virus virus diseases Epithelial Cells biochemical phenomena metabolism and nutrition 030104 developmental biology medicine.anatomical_structure Fusion mechanism |
| Zdroj: | Virology. 512 |
| ISSN: | 1096-0341 |
| Popis: | Syncytia formation has been considered important for cell-to-cell spread and pathogenesis of many viruses. As a syncytium forms, individual nuclei often congregate together, allowing close contact of nuclear membranes and possibly fusion to occur. However, there is currently no reported evidence of nuclear membrane fusion between adjacent nuclei in wild-type virus-induced syncytia. Varicella-zoster virus (VZV) is one typical syncytia-inducing virus that causes chickenpox and shingles in humans. Here, we report, for the first time, an interesting observation of apparent fusion of the outer nuclear membranes from juxtaposed nuclei that comprise VZV syncytia both in ARPE-19 human epithelial cells in vitro and in human skin xenografts in the SCID-hu mouse model in vivo. This work reveals a novel aspect of VZV-related cytopathic effect in the context of multinucleated syncytia. Additionally, the information provided by this study could be helpful for future studies on interactions of viruses with host cell nuclei. |
| Databáze: | OpenAIRE |
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