The role of gut-derived oxidized lipids and bacterial lipopolysaccharide in systemic inflammation and atherosclerosis
| Autor: | Wang, Huan, Reddy, Srinivasa T, Fogelman, Alan M |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Lipopolysaccharides
HDL Lipoproteins Endocrinology Diabetes and Metabolism Clinical Sciences Medical Biochemistry and Metabolomics Cardiorespiratory Medicine and Haematology Cardiovascular Oral and gastrointestinal apolipoprotein A-I mimetic peptides Chylomicrons Genetics Humans Molecular Biology Phospholipids Inflammation Nutrition and Dietetics human immunodeficiency virus lipopolysaccharide Cell Biology Atherosclerosis Cardiovascular System & Hematology oxidized phospholipids Digestive Diseases Lipoproteins HDL Cardiology and Cardiovascular Medicine |
| Zdroj: | Current opinion in lipidology, vol 33, iss 5 |
| ISSN: | 1473-6535 0957-9672 |
| Popis: | Purpose of reviewThis review explores mechanisms by which gut-derived bacteriallipopolysaccharide (LPS) and oxidized phospholipids contribute to chronic systemic inflammation and atherosclerosis.Recent findingsGut-derived LPS enters through the small intestine via two distinct pathways that involve high density lipoproteins (HDL) and chylomicrons. Gut-derived LPS can bind to the LPS-binding protein (LBP) and to HDL 3 in the small intestine and travel through the portal vein to the liver where it does not elicit an inflammatory reaction, and is inactivated or it can bind to HDL 2 and travel through the portal vein to the liver where it elicits an inflammatory reaction. Alternatively, in the small intestine, LPS can bind to LBP and chylomicrons and travel through the lymphatics to the systemic circulation and enhance inflammatory processes including atherosclerosis. Oxidized phospholipids formed in the small intestine regulate the levels and uptake of LPS in small intestine by regulating antimicrobial proteins such as intestinal alkaline phosphatase. Gut-derived LPS and oxidized phospholipids may be responsible for the persistent inflammation seen in some persons with human immunodeficiency virus on potent antiretroviral therapy with undetectable virus levels.SummaryBy targeting gut-derived oxidized phospholipids, the uptake of gut-derived LPS may be reduced to decrease systemic inflammation and atherosclerosis. |
| Databáze: | OpenAIRE |
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