A guanylurea ligand and its Cu(II), Ni(II) and Zn(II) complexes: antibacterial activities and DNA binding properties
| Autor: | Seda Nur Kertmen Kurtar, Ozge Gungor, Feridun Kocer, Muhammet Kose |
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| Rok vydání: | 2020 |
| Předmět: |
Chemistry
Binding properties 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Ligand (biochemistry) 01 natural sciences 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound Polymer chemistry Physical and Theoretical Chemistry 0210 nano-technology DNA |
| DOI: | 10.6084/m9.figshare.12852255 |
| Popis: | New Cu(II), Ni(II), Zn(II) complexes of a guanylurea ligand were synthesized and their structures were characterized by spectroscopic and analytical methods. The ligand was prepared by the hydrolysis of dicyandiamine in the presence of glacial acetic acid and obtained as acetate salt (HL·OAc). Molecular structure of the ligand and its Cu(II) complex were determined by single crystal X-ray diffraction studies. In the structure of the Cu(II) complex, each Cu(II) ion is four-coordinate with an approximate square planar geometry. The structures of the ligand and its Cu(II) complex were stabilized by hydrogen bond interactions. Antibacterial activity of the complexes was evaluated by single disk method. The complexes exhibit antibacterial activity. The synthesized compounds were screened for their FSds-DNA properties and Zn(II) complex showed higher binding affinity than free ligand and its Cu(II) and Ni(II) complexes. |
| Databáze: | OpenAIRE |
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