G-protein beta-3 subunit gene C825 T polymorphism: Influence on plasma sodium and potassium concentrations in essential hypertensive patients
| Autor: | Pablo Stiefel García-Junco, José Villar Ortiz, Ovidio Muñiz Grijalvo, Reposo Ramírez Lorca, María Luisa Miranda Guisado, Reyes Aparicio Santos, Ignacio Vallejo Maroto, Joaquín Carneado de la Fuente, Dolores Nieto Martín, Encarnación Pamies Andreu |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Beta-3 adrenergic receptor medicine.medical_specialty Sodium Potassium Natriuresis chemistry.chemical_element Blood Pressure Sodium Chloride Essential hypertension Plasma renin activity General Biochemistry Genetics and Molecular Biology Internal medicine Renin Renin–angiotensin system medicine Humans Genetic Predisposition to Disease General Pharmacology Toxicology and Pharmaceutics Polymorphism Genetic Chemistry Sodium Dietary General Medicine medicine.disease Heterotrimeric GTP-Binding Proteins Endocrinology Hypertension Female GNB3 |
| Zdroj: | Life Sciences. 77:2879-2886 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2005.02.030 |
| Popis: | The C825T polymorphism of the beta-3 subunit of the protein G (GNB3) has been related to an increased activity of the Na+/H+ exchanger (NHE-1) through the synthesis of an anomalous hyperactive protein. Because of the important role of this system in essential hypertension (EH), we analysed the distribution of the different genotypes of this polymorphism in normotensive subjects (NS) and essential hypertensive patients (EHP), their relationship with the condition of salt sensitivity, plasma sodium and potassium concentrations and plasma renin activity (PRA) in EHP. 144 subjects (78 EHP and 76 NS) were studied. Salt sensitivity was assessed by the rapid protocol of Weinberger and genotype determination for GNB3 C825T polymorphism was performed by PCR. The distribution of the different genotypes was similar among EHP (CC 37.2%; CT 41.1%; TT 16.7%) and NS (CC 32.9%; CT 55.3%; TT 11.8%). In regard to general characteristics of EHP (including blood pressure levels) and the condition of salt sensitivity, there were no differences among the different genotypes. Plasma sodium concentration was higher and plasma potassium was lower in TT patients (141.0+/-1.7 and 3.7+/-0.1) than in CC patients (139.1+/-1.9 and 4.0+/-0.3) p |
| Databáze: | OpenAIRE |
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