Histopathological features of bisphosphonates related osteonecrosis of the jaw in rats with and without vitamin d supplementation
Autor: | Tuncer Demir, Mutan Hamdi Aras, Saim Yanık, Sedat Çetiner, Suna Erkiliç, Zehra Bozdag |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Vitamin
Male medicine.medical_specialty medicine.medical_treatment Osteoclasts Gastroenterology Zoledronic Acid Dexamethasone 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine stomatognathic system Internal medicine medicine Vitamin D and neurology Maxilla Animals Rats Wistar Vitamin D General Dentistry Bisphosphonate-associated osteonecrosis of the jaw Osteoblasts Bone Density Conservation Agents Diphosphonates business.industry Orthognathic Surgical Procedures Imidazoles Osteonecrosis 030206 dentistry Cell Biology General Medicine medicine.disease Surgery Rats Disease Models Animal Zoledronic acid Otorhinolaryngology chemistry Dental extraction Jaw 030220 oncology & carcinogenesis Tooth Extraction Histopathology Bisphosphonate-Associated Osteonecrosis of the Jaw Osteonecrosis of the jaw business medicine.drug |
Popis: | Objective Aim of this study was to investigate the effect of vitamin-D3 on the osteonecrosis of bone that was induced after tooth extraction was conducted on rats that were given zoledronic acid (Z.A). Material and methods Animals were divided into four groups. Two of the experimental groups were divided into two subgroups, third study group was not divided into subgroups, and control group was divided into three subgroups. Z.A was administered twice per week over the course of 7 weeks, dexamethasone was administered twice a week during the 5th-6th-7th weeks to all groups. Dental extraction was performed by drilling around the tooth at 7th week. In study-group-1; vitamin-D was administered twice per week during the 5th-6th-7th weeks. In study-group 2; vitamin-D was administered twice per week during the 8th-9th-10th weeks. In study-group-3; vitamin-D was administered twice per week during the 15th-16th-17th weeks. The animals were sacrificed at 10th-15th-17th weeks, and histologic samples were taken. Results Postoperative-15-group had a lower osteoblast number, which was statistically significant as compared to preoperative-15 and control-15-group. Control-10-group showed significantly lower osteoclast number in comparison to preoperative-10 and postoperative-10-group. Osteoclast number was significantly higher in the osteonecrosis-17-group as compared to control-17-group. Preoperative-10-group showed significantly higher inflammation in comparison to control-10-group. Postoperative-15-group had a lower histologic osteonecrosis, which was statistically significant as compared to the control-15-group. Macroscopic osteonecrosis was significantly higher in the control-17-group in comparison to the osteonecrosis-17-group. Conclusions We concluded that there are some proofs for the treatment of BRONJ with systemic using of vitamin-D. |
Databáze: | OpenAIRE |
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