Histopathological features of bisphosphonates related osteonecrosis of the jaw in rats with and without vitamin d supplementation

Autor: Tuncer Demir, Mutan Hamdi Aras, Saim Yanık, Sedat Çetiner, Suna Erkiliç, Zehra Bozdag
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Vitamin
Male
medicine.medical_specialty
medicine.medical_treatment
Osteoclasts
Gastroenterology
Zoledronic Acid
Dexamethasone
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
stomatognathic system
Internal medicine
medicine
Vitamin D and neurology
Maxilla
Animals
Rats
Wistar
Vitamin D
General Dentistry
Bisphosphonate-associated osteonecrosis of the jaw
Osteoblasts
Bone Density Conservation Agents
Diphosphonates
business.industry
Orthognathic Surgical Procedures
Imidazoles
Osteonecrosis
030206 dentistry
Cell Biology
General Medicine
medicine.disease
Surgery
Rats
Disease Models
Animal
Zoledronic acid
Otorhinolaryngology
chemistry
Dental extraction
Jaw
030220 oncology & carcinogenesis
Tooth Extraction
Histopathology
Bisphosphonate-Associated Osteonecrosis of the Jaw
Osteonecrosis of the jaw
business
medicine.drug
Popis: Objective Aim of this study was to investigate the effect of vitamin-D3 on the osteonecrosis of bone that was induced after tooth extraction was conducted on rats that were given zoledronic acid (Z.A). Material and methods Animals were divided into four groups. Two of the experimental groups were divided into two subgroups, third study group was not divided into subgroups, and control group was divided into three subgroups. Z.A was administered twice per week over the course of 7 weeks, dexamethasone was administered twice a week during the 5th-6th-7th weeks to all groups. Dental extraction was performed by drilling around the tooth at 7th week. In study-group-1; vitamin-D was administered twice per week during the 5th-6th-7th weeks. In study-group 2; vitamin-D was administered twice per week during the 8th-9th-10th weeks. In study-group-3; vitamin-D was administered twice per week during the 15th-16th-17th weeks. The animals were sacrificed at 10th-15th-17th weeks, and histologic samples were taken. Results Postoperative-15-group had a lower osteoblast number, which was statistically significant as compared to preoperative-15 and control-15-group. Control-10-group showed significantly lower osteoclast number in comparison to preoperative-10 and postoperative-10-group. Osteoclast number was significantly higher in the osteonecrosis-17-group as compared to control-17-group. Preoperative-10-group showed significantly higher inflammation in comparison to control-10-group. Postoperative-15-group had a lower histologic osteonecrosis, which was statistically significant as compared to the control-15-group. Macroscopic osteonecrosis was significantly higher in the control-17-group in comparison to the osteonecrosis-17-group. Conclusions We concluded that there are some proofs for the treatment of BRONJ with systemic using of vitamin-D.
Databáze: OpenAIRE
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