Improvement of Meloxicam Solubility Using a β-Cyclodextrin Complex Prepared via the Kneading Method and Incorporated into an Orally Disintegrating Tablet
| Autor: | Syaiful Choiri, Muhamad Ali Azhari, Sholichah Rohmani, Ahmad Ainurofiq, Bambang Budi Suryadi, Chaterin Romauli Siagian, Fea Prihapsara |
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| Rok vydání: | 2015 |
| Předmět: |
Orally disintegrating tablet
Materials science Mixing (process engineering) Pharmaceutical Science 02 engineering and technology Meloxicam 030226 pharmacology & pharmacy Quality by Design Kneading 03 medical and health sciences 0302 clinical medicine Differential scanning calorimetry General Pharmacology Toxicology and Pharmaceutics Fourier transform infrared spectroscopy Solubility Quality by design chemistry.chemical_classification Chromatography Cyclodextrin lcsh:RM1-950 021001 nanoscience & nanotechnology Solvent lcsh:Therapeutics. Pharmacology chemistry β-cyclodextrin 0210 nano-technology Research Article |
| Zdroj: | Advanced Pharmaceutical Bulletin, Vol 6, Iss 3, Pp 399-406 (2016) |
| ISSN: | 2228-5881 |
| Popis: | Purpose: The aim of this research was to formulate and develop an orally disintegrating tablet (ODT) that incorporated a MEL/β-CD complex, using a quality by design (QbD) approach to enhance solubility and drug release. Methods: Multiple regression linear analysis was conducted to develop the kneading process and ODT formulation. Mixing time and amount of solvent were used as independent variables in kneading process optimisation, while the superdisintegrants were used to obtain the desired formulation. Fourier transform infrared spectroscopy and differential scanning calorimetry were performed for complex characterization. Results: MEL/β-CD complexation was successful in enhancing MEL solubility. The results suggest that increasing the amount of solvent and mixing time enhances drug loading and drug release. However, increased solvent amounts present the problem of removing the solvent. Primojel and Polyplasdone had a significant effect on the water wicking and tablet disintegration process (p |
| Databáze: | OpenAIRE |
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