Antidepressant action of transcranial direct current stimulation in olfactory bulbectomised adolescent rats
| Autor: | Roger Raymond, José N. Nobrega, Joshua Dean Conway, Sm Nageeb Hasan, Jacqueline Blundell, Shannon C Waye, O Chandani Dinesh, Francis Rodriguez Bambico |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_treatment Serotonin reuptake inhibitor Transcranial Direct Current Stimulation Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Animals Medicine Pharmacology (medical) RNA Messenger Depression (differential diagnoses) Serotonin Plasma Membrane Transport Proteins Pharmacology Transcranial direct-current stimulation Depression business.industry Brain-Derived Neurotrophic Factor Combined Modality Therapy Olfactory Bulb Paroxetine Rats 030227 psychiatry Disease Models Animal Psychiatry and Mental health Action (philosophy) Receptor Serotonin 5-HT1A Antidepressant business Neuroscience Selective Serotonin Reuptake Inhibitors 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Psychopharmacology. 35:1003-1016 |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | Background: Antidepressant drugs in adolescent depression are sometimes mired by efficacy issues and paradoxical effects. Transcranial direct current stimulation (tDCS) could represent an alternative. Aims/methods: We tested the antidepressant action of prefrontal tDCS and paroxetine (20 mg/kg, intraperitoneal) in olfactory bulbectomised (OBX) adolescent rats. Using enzyme-linked immunosorbent assays and in situ hybridisation, we examined treatment-induced changes in plasma brain-derived neurotrophic factor (BDNF) and brain serotonin transporter (SERT) and 5-HT-1A mRNA. Results: OBX-induced anhedonia-like reductions in sucrose preference (SP) correlated with open field (OF) hyperactivity. These were accompanied by decreased zif268 mRNA in the piriform/amygdalopiriform transition area, and increased zif268 mRNA in the hypothalamus. Acute paroxetine (2 days) led to a profound SP reduction, an effect blocked by combined tDCS–paroxetine administration. Chronic (14 days) tDCS attenuated hyperlocomotion and its combination with paroxetine blocked OBX-induced SP reduction. Correlations among BDNF, SP and hyperlocomotion scores were altered by OBX but were normalised by tDCS–paroxetine co-treatment. In the brain, paroxetine increased zif268 mRNA in the hippocampal CA1 subregion and decreased it in the claustrum. This effect was blocked by tDCS co-administration, which also increased zif268 in CA2. tDCS-paroxetine co-treatment had variable effects on 5-HT1A receptors and SERT mRNA. 5-HT1A receptor changes were found exclusively within depression-related parahippocampal/hippocampal subregions, and SERT changes within fear/defensive response-modulating brainstem circuits. Conclusion: These findings point towards potential synergistic efficacies of tDCS and paroxetine in the OBX model of adolescent depression via mechanisms associated with altered expression of BDNF, 5-HT1A, SERT and zif268 in discrete corticolimbic areas. |
| Databáze: | OpenAIRE |
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