The development of gene therapy for diseases of the lung
| Autor: | Ian A. Pringle, Deborah R. Gill, S C Hyde, Lee A. Davies |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Lung Diseases
Cystic Fibrosis Genetic enhancement Genetic Vectors Acute respiratory distress medicine.disease_cause Bioinformatics Cystic fibrosis Cellular and Molecular Neuroscience medicine Animals Humans Vector (molecular biology) Lung cancer Molecular Biology Adeno-associated virus Lung Asthma Pharmacology business.industry Gene Transfer Techniques Cell Biology Genetic Therapy medicine.disease medicine.anatomical_structure Immunology Liposomes Molecular Medicine business |
| DOI: | 10.1007/s00018-003-3317-z |
| Popis: | The development of a successful gene therapy has many stages, including preclinical testing in animal models and proof of principle clinical studies. A variety of diseases affect the lung, which are candidates for gene therapy; this review will mainly focus on the diseases that have attracted the most attention and have therefore yielded the most progress, namely lung cancer and the monogenic disorder cystic fibrosis. Knowledge gained from clinical studies could eventually be applied to more complex lung conditions such as acute respiratory distress syndrome and asthma. In addition, increased gene transfer efficiencies could be obtained by appropriate selection of the gene transfer vector and mode of delivery. |
| Databáze: | OpenAIRE |
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