Food allergy in the Netherlands : differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients
| Autor: | Peter Burney, Stefan Vieths, En Clare Mills, Jonas Lidholm, Titia Lindner, Ischa Kummeling, Ronald van Ree, James Potts, Ans F.M. Lebens, Montserrat Fernandez-Rivas, Carla A.F.M. Bruijnzeel-Koomen, André C. Knulst, Alan R. Mackie, Barbara K. Ballmer-Weber, Thuy-My Le, Els van Hoffen |
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| Přispěvatelé: | University of Zurich, Le, Thuy-My, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Experimental Immunology |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pediatrics medicine.medical_specialty Allergy Immunology Population INTOLERANCE CHILDREN 610 Medicine & health Community DOUBLE-BLIND Food allergy Journal Article Medicine Outpatient clinic Adults Immunology and Allergy Clinical severity education Sensitization POPULATION DBPCFC education.field_of_study 2403 Immunology Science & Technology business.industry Research digestive oral and skin physiology 10177 Dermatology Clinic medicine.disease PREVALENCE medicine.anatomical_structure 2740 Pulmonary and Respiratory Medicine Dermatology clinic Unselected population 2723 Immunology and Allergy sIgE business CHALLENGE Life Sciences & Biomedicine |
| Zdroj: | Clinical and Translational Allergy, 5. BioMed Central Clinical and translational allergy, 5. BioMed Central Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Clinical and Translational Allergy |
| ISSN: | 2045-7022 |
| Popis: | BACKGROUND: It is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population. OBJECTIVE: To discover if FA in a random sample from the Dutch community is comparable to that of outpatients. METHODS: This study was part of the Europrevall-project. A random sample of 6600 adults received a questionnaire. Those with symptoms to one of 24 defined priority foods were tested for sIgE. Participants with a positive case history and elevated sIgE were evaluated by double-blind placebo-controlled food challenge (DBPCFC). Outpatients with a suspicion of FA were evaluated by questionnaire, sIgE and DBPCFC. RESULTS: In the community, severe symptoms were reported less often than in outpatients (39.3% vs. 54.3%). Participants in the community were less commonly sensitized to any of the foods. When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups. CONCLUSION: In the Netherlands, there are large differences in self-reported FA between community and outpatients. However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome. |
| Databáze: | OpenAIRE |
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