Design, synthesis, and antifungal activities of novel sulfoximine derivatives for plant protection

Autor: Yuan Liu, Hongsen Li, Yuequn Zhao, Yonghai Xie, Yuhong He, Yaxin Qin, Yingpan Wang, Junle Shi, Linjing Zhao, Ya Li, Wenrui Zheng
Rok vydání: 2023
Předmět:
Zdroj: Pest Management Science. 79:1273-1283
ISSN: 1526-4998
1526-498X
DOI: 10.1002/ps.7259
Popis: Fungicides play a significant role in the integrated management of plant pathogens. However, the irrational application of the fungicides with similar structures have led to development of cross-resistance. Therefore, the need to seek novel fungicides with new structure is desired.Twenty-eight novel sulfoximine derivatives incorporating nitroguanidine moieties were designed, synthesized, and evaluated as antifungal agents. The bioassay results indicated that most of the synthesized compounds displayed excellent fungicidal activities against Sclerotinia sclerotiorum, Rhizoctonia solani, Fusarium graminearum, and Pyricularia grisea. Among them, compounds 6cNovel sulfoximine derivatives containing nitroguanidine possess the potential antifungal activity, and the unique structure may offer an alternative option for fungicide development in the future. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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