Expression of toll-like receptors on B lymphocytes
| Autor: | Greg Hodge, Geoffrey W. Dandie, Heddy Zola, Ian C. Nicholson, Pallave Dasari |
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| Rok vydání: | 2005 |
| Předmět: |
Antigens
CD19 Immunology B-Lymphocyte Subsets chemical and pharmacologic phenomena CD5 Antigens CD19 Immune system immune system diseases medicine Humans B cell B-Lymphocytes Innate immune system biology Toll-Like Receptors Antibodies Monoclonal TLR9 hemic and immune systems Flow Cytometry Cell biology B-1 cell medicine.anatomical_structure Peripheral blood lymphocyte Leukocytes Mononuclear biology.protein Antibody |
| Zdroj: | Cellular Immunology. 236:140-145 |
| ISSN: | 0008-8749 |
| Popis: | Toll-like receptors (TLRs) are a family of trans-membrane receptors that play an important role in the innate immune system. Most studies examining the cellular expression of TLRs on immune cells have focussed on neutrophils, monocytes and dendritic cells, but there is little evidence of TLRs being expressed on lymphocytes. Using 3-colour flow cytometry, expression of TLR-1, TLR-2, TLR-3, TLR-4, and TLR-9 on peripheral blood lymphocyte populations was determined. Further examination of TLRs on CD5- and CD5+ CD19+ B cell subsets was performed. The binding of TLR1 and TLR9 antibodies was detected on 15-90% of resting B cells, but not on resting T-cells. The higher expression of TLR1 and TLR9 on CD5+ B cells compared to CD5- B cells may reflect the role of B1 cells in more primitive, less specific antibody responses. |
| Databáze: | OpenAIRE |
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