Proton range verification with ultrasound imaging using injectable radiation sensitive nanodroplets: a feasibility study
| Autor: | Jan D'hooge, Marcus Ingram, Sjoerd Nooijens, Emiliano D'Agostino, Sophie V. Heymans, Gaio Paradossi, Edmond Sterpin, Koen Van Den Abeele, Bram Carlier, Yosra Toumia, Uwe Himmelreich |
|---|---|
| Přispěvatelé: | UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie |
| Rok vydání: | 2020 |
| Předmět: |
Bubbles (in fluids)
Proton Proton beam therapy Physics::Medical Physics Bragg peak 7. Clean energy Phantoms 030218 nuclear medicine & medical imaging 0302 clinical medicine Nuclear magnetic resonance Settore CHIM/02 proton therapy Proton Therapy Nanotechnology Ultrasonics Linear Energy Transfer Ultrasonography Vaporization dosimetry Radiological and Ultrasound Technology Ultrasonic imaging ultrasound Phantoms Imaging Ultrasound nanodroplets Elastic cross sections 3. Good health 030220 oncology & carcinogenesis Nano-droplets Microbubbles Drops Nuclear reactions Monte Carlo Method Materials science Linear energy transfer Monoenergetic protons range verification 03 medical and health sciences Droplet vaporization High linear energy transfers Humans Radiology Nuclear Medicine and imaging Irradiation Proton therapy business.industry Reproducibility of Results Range verifications Energy transfer Proton beams Semi-empirical theory Feasibility Studies business Radiotherapy Image-Guided |
| Zdroj: | Physics in Medicine and Biology, Vol. 65, no. 6, p. 17 (2020) |
| ISSN: | 1361-6560 0034-4885 0031-9155 |
| Popis: | Technologies enabling in vivo range verification during proton therapy are actively sought as a means to reduce the clinical safety margins currently adopted to avoid tumor underdosage. In this contribution, we applied the semi-empirical theory of radiation-induced vaporization of superheated liquids to coated nanodroplets. Nanodroplets are injectable phase-change contrast agents that can vaporize into highly echogenic microbubbles to provide contrast in ultrasound images. We exposed nanodroplet dispersions in aqueous phantoms to monoenergetic proton beams of varying energies and doses. Ultrasound imaging of the phantoms revealed that radiation-induced droplet vaporization occurred in regions proximal to the proton Bragg peak. A statistically significant increase in contrast was observed in irradiated regions for doses as low as 2 Gy and found to be proportional to the proton fluence. The absence of enhanced response in the vicinity of the Bragg peak, combined with theoretical considerations, suggest that droplet vaporization is induced by high linear energy transfer (LET) recoil ions produced by nuclear reactions with incoming protons. Vaporization profiles were compared to non-elastic cross sections and LET characteristics of oxygen recoils. Shifts between the ultrasound image contrast drop and the expected proton range showed a sub-millimeter reproducibility. These early findings confirm the potential of superheated nanodroplets as a novel tool for proton range verification. ispartof: PHYSICS IN MEDICINE AND BIOLOGY vol:65 issue:6 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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