Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: New perspectives
| Autor: | David S. Warner, Cecil O. Borel, Ken Takata, Daniel T. Laskowitz, Huaxin Sheng, Frederick W. Lombard |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Neurons Subarachnoid hemorrhage Cognitive disorder Central nervous system Brain Morris water navigation task Subarachnoid Hemorrhage medicine.disease Rats Time medicine.anatomical_structure Degenerative disease Developmental Neuroscience Neurology Cerebral blood flow Anesthesia medicine Animals Rats Wistar Cognition Disorders Maze Learning Vascular dementia Psychology Perfusion |
| Zdroj: | Experimental Neurology. 213:336-344 |
| ISSN: | 0014-4886 |
| DOI: | 10.1016/j.expneurol.2008.06.009 |
| Popis: | Cognitive dysfunction is increasingly recognized as a significant long-term complication following subarachnoid hemorrhage (SAH), affecting up to 60% of survivors. We proposed to determine the incidence and explore potential mechanisms of cognitive dysfunction in a rat model. The effects of intracisternal blood, saline and sham injections were compared. At five weeks, Morris water maze escape latency (P=0.001) and swimming distance (P=0.001) were significantly different between groups, with increased latencies and distances recorded in the blood group in spite of increased swimming speed. The number of morphologically intact cortical (r=-0.75, P=0.0001) and hippocampal CA1 (r=-0.80, P |
| Databáze: | OpenAIRE |
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