An Ion‐Enhanced Oncolytic Virus‐Like Nanoparticle for Tumor Immunotherapy

Autor:	Fan Wu, Yanli Li, Yun Meng, Xuechao Cai, Jieyun Shi, Jinjin Li, Yang Chen, Li Zhang, Xianfu Meng, Huiyan Li, Xingwu Jiang, Zhenxiao Fu, Yelin Wu, Wenbo Bu
Rok vydání:	2022
Předmět:	Oncolytic Virotherapy Oncolytic Viruses Antigens Neoplasm Neoplasms Cell Line Tumor Humans Nanoparticles General Chemistry Immunotherapy General Medicine Catalysis
Zdroj:	Angewandte Chemie. 134
ISSN:	1521-3757 0044-8249
DOI:	10.1002/ange.202210487
Popis:	T lymphocytes (T cells) are essential for tumor immunotherapy. However, the insufficient number of activated T cells greatly limits the efficacy of tumor immunotherapy. Herein, we proposed an oncolytic virus-mimicking strategy to enhance T cell recruitment and activation for tumor treatment. We constructed an oncolytic virus-like nanoplatform (PolyIC@ZIF-8) that was degraded in the acidic tumor environment to release PolyIC and Zn
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cfb6499befa2adc1bf72be96defc6d https://doi.org/10.1002/ange.202210487 Zobrazit plný text záznamu