Heavy metal levels in patients with ineffective erythropoiesis
| Autor: | Orhan Gürsel, Sule Unal, Fatma Gumruk, Onur Erdem, Erdem Karabulut, İbrahim Eker, E. Çırak, Cemal Akay, Turan Bayhan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Ineffective erythropoiesis Adult Male medicine.medical_specialty Adolescent Thalassemia chemistry.chemical_element medicine.disease_cause Benzoates Divalent 03 medical and health sciences 0302 clinical medicine Internal medicine Metals Heavy medicine Humans Chelation Erythropoiesis Child Anemia Dyserythropoietic Congenital chemistry.chemical_classification Cadmium biology Deferasirox beta-Thalassemia Hematology DMT1 Triazoles medicine.disease 030104 developmental biology Endocrinology chemistry 030220 oncology & carcinogenesis Child Preschool biology.protein Female Congenital dyserythropoietic anemia medicine.drug |
| Zdroj: | Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 56(4) |
| ISSN: | 1473-0502 |
| Popis: | Objectives Iron is taken into enterocytes at the duodenum via apical divalent metal-ion transporter 1 protein. Besides iron, divalent metal-ion transporter 1 also transports other divalent metals. We aimed to investigate blood heavy metal levels in patients with ineffective erythropoiesis. Methods Blood levels of heavy metals including Pb, Al, Cd, Cr, Co, Cu, and Zn were measured in patients with thalassemia major (TM), thalassemia intermedia (TI), congenital dyserythropoietic anemia (CDA), and age- and sex-matched healthy controls. Results Blood samples were obtained from 68 patients (51 patients with TM, 8 with TI, 9 with CDA), and a control group that included 65 volunteers. Patients with TM were found to have lower Al, Pb, and Zn, and higher Cd levels compared with the control group. The patients treated with deferasirox were further analyzed and Pb and Zn levels were found lower compared with the control group. Discussion Patients with TM had tendency to have elevated levels of plasma cadmium; however, the median level was not at a toxic level. Increased metal-ion transporter 1 activity may cause heavy metal accumulation, but deferasirox chelation may be protective against heavy metals besides iron. |
| Databáze: | OpenAIRE |
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