Nonalcoholic fatty liver disease (NAFLD) without insulin resistance: Is it different?
| Autor: | Chudamani Meher, Debasis Misra, Shivaram Prasad Singh, Manorama Swain, Kaumudee Pattnaik, Bijay Misra, Niranjan Rout, Omprakash Agrawal, Sanjib Kumar Kar, Manas Kumar Panigrahi, Pallavi Bhuyan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Liver Cirrhosis Male medicine.medical_specialty Pathology Adolescent Population India Gastroenterology Transaminase chemistry.chemical_compound Young Adult Insulin resistance Fibrosis Cholelithiasis Non-alcoholic Fatty Liver Disease Internal medicine Nonalcoholic fatty liver disease Diabetes Mellitus Medicine Humans Insulin Obesity Young adult education Transaminases Triglycerides Aged Retrospective Studies Ultrasonography Aged 80 and over education.field_of_study Hepatology Triglyceride business.industry Middle Aged medicine.disease chemistry Elevated transaminases Female Insulin Resistance business Hepatomegaly |
| Zdroj: | Clinics and research in hepatology and gastroenterology. 39(4) |
| ISSN: | 2210-741X |
| Popis: | Summary Background and aims Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of insulin resistance [IR]. However, a significant proportion of NAFLD patients are devoid of IR. Is NAFLD sans IR a different entity? The aim of the study was to compare the anthropometric, metabolic, biochemical, ultrasonography, and histological profile of NAFLD patients with and without IR. Methods Retrospective analyses of 336 NAFLD patients diagnosed during the last two years was done. Patients without IR were compared with those with IR. Results Out of 336 patients, 153 [45.53%] were without IR. Although age, gender, BMI and transaminase levels were comparable, significantly higher proportion of patients in non-IR group were non-obese [43.14% vs. 25/14%; P = 0.0005], and had mild fatty change on ultrasonography; [78.43% vs. 67.21%; P = 0.022]. Higher proportion of them had elevated transaminases; [67.97% vs. 56.83%; P = 0.036]. Serum triglyceride [178.52 ± 78.78 vs. 204.86 ± 94.72 mg/dl; P = 0.02], FBG [85.39 ± 13.80 vs. 98.93 ± 31.56 mg/dl; P = 0.00], PGBG [123.76 ± 36.77 vs. 148.07 ± 64.67 mg/dl; P = 0.00], and serum insulin [6.33 ± 2.18 vs. 15.39 ± 12.56 μIU/ml; P = 0.00] were significantly lower in patients without IR. Although there was no difference in histology, interestingly fibrosis was seen in one third of patients despite absence of IR. Conclusion Nearly half of our NAFLD population was without IR; one third of them had significant fibrosis. NAFLD is probably a heterogeneous disease and IR is not the sole factor responsible for NAFLD; further studies are needed to find out other possible etiological factors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect