Renal Effects of A Nonhypotensive IV Dose of Felodipine
| Autor: | Jean R. Cusson, B. Edgar, G. Thibault, P. du Souich, Pierre Larochelle |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Metabolic Clearance Rate Diuresis Blood Pressure Kidney Plasma renin activity Natriuresis chemistry.chemical_compound Double-Blind Method Internal medicine medicine Humans Pharmacology (medical) Infusions Intravenous Pharmacology Aldosterone Felodipine Renal sodium reabsorption Endocrinology medicine.anatomical_structure chemistry Renal blood flow Vascular Resistance Pharmaceutical Vehicles Glomerular Filtration Rate medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 33:732-737 |
| ISSN: | 0091-2700 |
| DOI: | 10.1002/j.1552-4604.1993.tb05615.x |
| Popis: | To evaluate the natriuretic effect of a nonhypotensive dose of felodipine, 11 healthy volunteers (age: 21-28 years) on a high-sodium diet received the drug or its vehicle in a double-blind, randomized, crossover study. Administered intravenously at a dose level of 7.5 micrograms/min for 30 minutes followed by 5 micrograms/min for 120 minutes, felodipine increased natriuresis (546 +/- 69 vs. 454 +/- 39 mumol/min, P < 0.001) and diuresis (8.9 +/- 0.6 vs. 7.5 +/- 0.5 mL/min), compared to its vehicle. Renal plasma flow tended to be augmented, but there was a significant reduction of renal vascular resistance (0.085 +/- 0.004 vs. 0.101 +/- 0.012 mm Hg/mL/min, P < 0.03). The glomerular filtration rate was slightly decreased and proximal sodium reabsorption was diminished with no measurable effect on distal function. Felodipine stimulated plasma renin activity, but produced no changes in plasma atrial natriuretic factor, cGMP, aldosterone, and atrial vasopressin levels. In conclusion, felodipine induced natriuresis and diuresis while reducing proximal tubular sodium reabsorption. |
| Databáze: | OpenAIRE |
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