Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients
| Autor: | Zorana Jelic-Ivanovic, Violeta Vucinic-Mihailovic, Jelena Kotur-Stevuljevic, Jasmina Ivanisevic, Aleksandra Stefanovic, Jelica Videnovic-Ivanov, Slavica Spasic |
|---|---|
| Jazyk: | srbština |
| Rok vydání: | 2017 |
| Předmět: |
Pharmaceutical Science
lcsh:RS1-441 Inflammation inflamacija Matrix metalloproteinase 030226 pharmacology & pharmacy lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine sarkoidoza matrix metalloproteinase-9 medicine 030212 general & internal medicine tkivni inhibitor matriks metaloproteinaza-1 sarcoidosis tissue inhibitor of matrix metalloproteinase-1 Pharmacology Chemistry Matrix metalloproteinase 9 medicine.disease 3. Good health inflammation Cancer research Sarcoidosis medicine.symptom matriks metaloproteinaza-9 |
| Zdroj: | Arhiv za farmaciju, Vol 67, Iss 1, Pp 1-13 (2017) Arhiv za farmaciju (2017) 67(1):1-13 Arhiv za farmaciju |
| ISSN: | 2217-8767 0004-1963 |
| Popis: | Matrix metaloproteinases (MMPs) and their specific inhibitors - tissue inhibitors of matrix metalloproteinases (TIMPs) play an important role in pulmonary extracellular matrix destruction. Sarcoidosis is an inflammatory disease affecting multiple organs. It has been reported that MMP-9 and TIMP-1 levels were increased in bronchoalveolar lavage fluid and induced sputum of sarcoidosis patients. The aim of our study was to evaluate MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations and MMP-9/TIMP-1 ratio in sarcoidosis patients, their relationship with inflammatory markers and their ability do predict the existence of disease. We included 101 sarcoidosis patients and 50 healthy subjects. Serum samples were analyzed. Besides routine biochemical parameters, high-sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations were measured. MMP-9 (P lt 0.05), hsCRP, SAA and TIMP-1 (P lt 0.001) concentrations were significantly increased in patients whereas MMP-9/TIMP-1 complex was higher in patients, but with marginal significance. In sarcoidosis, TIMP-1 correlated significantly positively with inflammatory parameters (P lt 0.05). Uni-variate analysis showed that MMP-9, TIMP-1, hsCRP and SAA had the ability to predict the existence of sarcoidosis. In the model consisted of MMP- 9, TIMP-1, hsCRP and SAA, only SAA remained significant predictor of disease (P lt 0.01). Results showed the significance of MMP-9 and TIMP-1 in sarcoidosis. Matriks metaloproteinaze (MMP) i tkivni inhibitori matriks metaloproteinaza (TIMP) imaju značajnu ulogu u destrukciji plućnog ekstracelularnog matriksa. Sarkoidoza je inflamatorno oboljenje koje zahvata različite organe. Utvrđeno je da su koncentracije MMP-9 i TIMP-1 povećane u bronhoalveolarnom lavatu i sputumu pacijenata sa sarkoidozom. Cilj naše studije je bio da se odrede koncentracije MMP-9, TIMP-1 i MMP-9/TIMP-1 kompleksa, MMP- 9/TIMP-1 odnosa u sarkoidozi, njihova povezanost sa parametrima inflamacije, kao i njihov potencijal za predviđanje postojanja bolesti. Ispitivanjem su obuhvaćeni 101 pacijent sa sarkoidozom i 50 zdravih ispitanika. Analizirani su uzorci seruma. Pored rutinskih biohemijskih parametara, merene su koncentracije visoko-osetljivog C-reaktivnog proteina (hsCRP), serumskog amiloida A (SAA), MMP-9, TIMP-1 i MMP-9/TIMP-1 kompleksa. MMP-9 (P lt 0,05), hsCRP, SAA i TIMP-1 (P lt 0,001) su bili značajno veći kod pacijenata dok je koncentracija MMP-9/TIMP-1 kompleksa bila veća, ali sa graničnom značajnošću. U sarkoidozi, TIMP-1 je značajno pozitivno korelirao sa inflamatornim parametrima (P lt 0,05). Uni-varijantna analiza je pokazala da su MMP-9, TIMP-1, hsCRP i SAA imali značajan potencijal za predviđanje postojanja bolesti. U modelu koji je sadržao MMP-9, TIMP-1, hsCRP i SAA, samo SAA je ostao značajan u ovom predviđanju (P lt 0,01). Rezultati pokazuju značaj MMP-9 i TIMP-1 u sarkoidozi. |
| Databáze: | OpenAIRE |
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