Unresponsive Severe Aplastic Anemia in a Young Patient: Case Report and Short Review of the Literature
| Autor: | Diana Popescu, Nicoleta Dima, Ana-Roxana Gănceanu-Rusu, Oana Viola Badulescu, Minerva Codruța Bădescu, Ciprian Rezuș |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty bone marrow aplastic anemia business.industry General Medicine Severe Aplastic Anemia horse anti-thymocyte globulin 03 medical and health sciences medullary aplasia 0302 clinical medicine hemic and lymphatic diseases 030220 oncology & carcinogenesis medicine Medicine eltrombopag business 030215 immunology |
| Zdroj: | Journal of Interdisciplinary Medicine, Vol 6, Iss 2, Pp 116-119 (2021) |
| ISSN: | 2501-8132 |
| Popis: | Aplastic anemia or medullary aplasia is a medical condition characterized by pancytopenia and is associated with a high prevalence of morbidity and mortality. In patients in whom bone marrow transplantation cannot be attempted, an immunosuppressive regimen is considered to be the first-line therapy. Also, the addition of eltrombopag from the first day of immunosuppressive treatment seems to significantly increase response rate. Unfortunately, there are a small number of patients who remain unresponsive to all these therapies. Here we present the case of a young woman who was referred by the family doctor complaining of marked physical asthenia, new onset dyspnea, and dizziness. Apart from a severe pancytopenia, no further changes have been brought to light by paraclinical investigations. After multiple secondary causes were excluded, the patient was diagnosed with idiopathic aplastic anemia. Even if bone marrow transplant was the first-line therapy in this case, because of the severe leukopenia, it was not possible to determine the HLA type. Therefore, the patient was prescribed immunosuppressive treatment. Despite the three drug-associated therapy (horse anti-thymocyte globulin, cyclosporin A, and eltrombopag), the response was unsatisfactory, with the persistence of severe pancytopenia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|