Serum interleukin-6, interleukin-8, andβ 2-Microglobulin in early assessment of severity of acute pancreatitis comparison with serum C-reactive protein
Autor: | R. Pezzilli, Rita Miniero, Onda Cappelletti, Antonio Maria Morselli-Labate, Manuela Fiocchi, Bahjat Barakat, Mario Miglioli, G. Sprovieri, Paola Billi |
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Rok vydání: | 1995 |
Předmět: |
Adult
Male medicine.medical_specialty Pathology Time Factors Pancreatic disease Adolescent Physiology Sensitivity and Specificity Gastroenterology Internal medicine medicine Humans Interleukin 6 Aged Aged 80 and over biology Interleukin-6 Beta-2 microglobulin business.industry Interleukin-8 C-reactive protein Liter Middle Aged Hepatology medicine.disease C-Reactive Protein Pancreatitis ROC Curve Acute Disease biology.protein Acute pancreatitis Female beta 2-Microglobulin business |
Zdroj: | Digestive Diseases and Sciences. 40:2341-2348 |
ISSN: | 1573-2568 0163-2116 |
Popis: | The aim of this study was to compare the sensitivity, specificity, and diagnostic accuracy of serum interleukin-6, interleukin-8, beta 2-microglobulin, and C-reactive protein in the assessment of the severity of acute pancreatitis using commercial kits for their respective assays. Thirty-eight patients with acute pancreatitis (25 men, 13 women, mean age 59 years, range 16-97) were studied; the diagnosis was based on prolonged upper abdominal pain associated with a twofold increase of serum lipase, and it was confirmed by imaging techniques. According to the Atlanta criteria, 15 patients had severe illness and 23 had mild disease. The four serum markers were determined in all patients on admission, as well as daily for the following five days. On the first day of the disease, the sensitivity (calculated on patients with severe pancreatitis), specificity (calculated on patients with mild pancreatitis), and the diagnostic accuracy of these serum markers for establishing the severity of acute pancreatitis were 100%, 86%, and 91% for interleukin-6 (cutoff level 2.7 pg/ml); 100%, 81% and 88% for interleukin-8 (cutoff level 30 pg/ml); 58%, 81%, and 73% for beta 2-microglobulin (cutoff level 2.1 mg/liter); and 8%, 95%, and 64% for C-reactive protein (cutoff level 11 mg/dl). The results of our study indicate that, when assayed during the first 24 hr of disease onset, interleukin-6 and interleukin-8 are better markers than beta 2-microglobulin or C-reactive protein for evaluating the severity of acute pancreatitis. |
Databáze: | OpenAIRE |
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