Clinical Trials Targeting Secondary Damage after Traumatic Spinal Cord Injury
| Autor: | Zin Z. Khaing, Jessica Y. Chen, Gevick Safarians, Sohib Ezubeik, Nicolas Pedroncelli, Rebecca D. Duquette, Tobias Prasse, Stephanie K. Seidlits |
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| Rok vydání: | 2023 |
| Předmět: |
spinal cord injury repair
Physical Injury - Accidents and Adverse Effects Clinical Trials and Supportive Activities Neurodegenerative Regenerative Medicine Catalysis Inorganic Chemistry Clinical Research Genetics Humans Physical and Theoretical Chemistry Spinal Cord Injury Molecular Biology Spinal Cord Injuries Traumatic Head and Spine Injury Spectroscopy Clinical Trials as Topic Chemical Physics neuroprotective therapies Organic Chemistry Neurosciences Injuries and accidents General Medicine acute and sub-acute strategies Computer Science Applications Neuroprotective Agents Spinal Cord Neurological Quality of Life Other Biological Sciences Other Chemical Sciences biomaterials |
| Zdroj: | International journal of molecular sciences, vol 24, iss 4 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms24043824 |
| Popis: | Spinal cord injury (SCI) often causes loss of sensory and motor function resulting in a significant reduction in quality of life for patients. Currently, no therapies are available that can repair spinal cord tissue. After the primary SCI, an acute inflammatory response induces further tissue damage in a process known as secondary injury. Targeting secondary injury to prevent additional tissue damage during the acute and subacute phases of SCI represents a promising strategy to improve patient outcomes. Here, we review clinical trials of neuroprotective therapeutics expected to mitigate secondary injury, focusing primarily on those in the last decade. The strategies discussed are broadly categorized as acute-phase procedural/surgical interventions, systemically delivered pharmacological agents, and cell-based therapies. In addition, we summarize the potential for combinatorial therapies and considerations. |
| Databáze: | OpenAIRE |
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