Hypovascular hepatic nodules showing hypointense on the hepatobiliary-phase image of Gd-EOB-DTPA-enhanced MRI to develop a hypervascular hepatocellular carcinoma: a nationwide retrospective study on their natural course and risk factors
| Autor: | Keiko Korenaga, Kazuaki Chayama, Takeshi Suda, Hiroshi Aikata, Masatoshi Kudo, Azusa Sakamoto, Kennichi Miyoshi, Hiroko Iijima, Tomoko Hyodo, Tatsuo Inoue, Kazushi Numata, Masashi Hirooka, Masahiko Koda, Yukio Osaki, Hironori Tanaka, Akihiro Nishie, Toru Takano, Yasuharu Imai, Yukihisa Takayama, Hironori Ochi, Takamichi Murakami, Atsushi Higaki |
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| Rok vydání: | 2013 |
| Předmět: |
Gadolinium DTPA
Male medicine.medical_specialty Carcinoma Hepatocellular Japan Risk Factors medicine Carcinoma Humans Cumulative incidence Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test Proportional hazards model business.industry Liver Neoplasms Gastroenterology Retrospective cohort study Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Hyperintensity Hepatocellular carcinoma Relative risk Multivariate Analysis Disease Progression Female Radiology Bile Ducts Nuclear medicine business |
| Zdroj: | Digestive diseases (Basel, Switzerland). 31(5-6) |
| ISSN: | 1421-9875 |
| Popis: | Objective: We aimed to investigate the natural outcome of nonhypervascular lesions detected in the hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI by performing a longitudinal study retrospectively enrolled in a nationwide manner. Methods: Between February 2008 and March 2011, 224 patients with 504 nodules that were diagnosed as nonhypervascular by imaging were recruited from institutions that participated in the present study. We examined the natural outcome of nonhypervascular lesions and evaluated the risk factors. Results: Of the 504 nodules, 173 (34.3%) showed hypervascular transformation. The overall cumulative incidence of hypervascular transformation was 14.9% at 12 months and 45.8% at 24 months. Multivariate analysis using the Cox regression model revealed previous treatment history for hepatocellular carcinoma (HCC; relative risk = 1.498; p = 0.036, 95% CI 1.03-2.19) and hyperintensity on T2-weighted images (relative risk = 1.724; p = 0.015, 95% CI 1.11-2.67) were identified as independent factors for hypervascular transformation. Conclusions: Patients who have a previous treatment history for HCC and with hypointense nodules showing hyperintensity on T2-weighted images need careful follow-up because of the high incidence of hypervascular transformation. |
| Databáze: | OpenAIRE |
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