Synthesis and QSAR Study of (4-Oxo-3-aryl-3,4-dihydro-quinazolin-2-ylsulfanyl)-propionic Acid arylidene/aryl-ethylidene-hydrazides via Microwave Assisted Solvent Free Reations

Autor:	Savita Dhongade, M. B. Deshmukh
Rok vydání:	2004
Předmět:	chemistry.chemical_classification Quantitative structure–activity relationship Aryl Hydrazine Thio General Chemistry Alkylation Microwave assisted lcsh:Chemistry chemistry.chemical_compound lcsh:QD1-999 chemistry Propionate Organic chemistry Hydrate
Zdroj:	E-Journal of Chemistry, Vol 1, Iss 2, Pp 115-126 (2004)
ISSN:	2090-9810 0973-4945
Popis:	In the present work,s-alkylated derivatives of thio-quinazolinone were obtained using Methyl 2-chloro propionate via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazides, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. . The relationship between structure and different biological activities was studied and the different derivatives were recommended for the screening of some specific activities like anti-tuberculosic, anti-mycobacterial & HDL cholesterol increasing activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bfe5a78cb07ed88e211c487f26914d https://doi.org/10.1155/2004/142148 Zobrazit plný text záznamu