Oropharyngeal samples versus lesion specimens at diagnosis in patients infected with monkeypox virus in Northern France

Autor: Mahdi Ouafi, Alexandre Regueme, Isabelle Alcaraz, Pierre Riviere, Helène Bazus, Arnaud Salmon‐Rousseau, Bertrand Cappeliez, Noémie Cartier, Aurélie Guigon, Mouna Lazrek, Laurence Bocket, Emmanuel Faure, Olivier Robineau, Didier Hober, Enagnon Kazali Alidjinou
Rok vydání: 2022
Předmět:
Zdroj: Journal of medical virologyREFERENCES. 95(1)
ISSN: 1096-9071
Popis: The ongoing outbreak of monkeypox virus (MPXV) is the largest one in historically non-endemic countries. Early reports described atypical epidemiological and clinical presentations. We investigated MPXV DNA detection in oropharyngeal samples (OPS), and compared the viral load to that in lesion samples at diagnosis in patients infected with MPXV. We retrospectively included patients suspected to have monkeypox in Northern France, who underwent a MPXV PCR in the Virology Laboratory, University Hospital of Lille, from May 23 to August 18, 2022. Overall, a total of 228 patients (376 samples) were included. A positive result in at least one sample was found in 138 patients (60.5%). We compared PCR results between OPS and lesion samples (i.e., cutaneous or anal/rectal samples) in patients with both samples. A positive result in OPS was observed in 54 out of 60 patients (90%). The viral load in OPS (median C
Databáze: OpenAIRE