A double-blind randomized controlled trial of antenatal mebendazole to reduce low birthweight in a hookworm-endemic area of Peru
| Autor: | Julio C. Soto, Renée Larocque, Martin Casapia, Eduardo Gotuzzo, J. Dick MacLean, Elham Rahme, Gyorkos Tw |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Endemic Diseases Anemia Birth weight Mebendazole Population Placebo law.invention Hookworm Infections Double-Blind Method Randomized controlled trial Pregnancy law Peru Prevalence medicine Humans Pregnancy Complications Infectious education education.field_of_study business.industry Antinematodal Agents Pregnancy Complications Hematologic Infant Newborn Public Health Environmental and Occupational Health Infant Low Birth Weight medicine.disease Malaria Low birth weight Infectious Diseases Female Parasitology medicine.symptom business medicine.drug |
| Zdroj: | Tropical Medicine and International Health. 11:1485-1495 |
| ISSN: | 1365-3156 1360-2276 |
| DOI: | 10.1111/j.1365-3156.2006.01706.x |
| Popis: | The objective was to assess the effect on birthweight of antenatal mebendazole plus iron vs. placebo plus iron in a highly hookworm-endemic area. Double-blind randomized controlled trial set in rural and peri-urban communities in the Peruvian Amazon region. A total of 1042 second trimester pregnant women between the ages of 18 and 44 years were recruited from April to November 2003 and followed to July 2004. Women were randomly assigned to receive either mebendazole (500 mg single dose) plus iron supplements (60 mg elemental iron daily) or placebo plus iron supplements. The primary outcome was mean infant birthweight and secondary measures included proportion of low birthweight babies and maternal anaemia. The prevalence of hookworm infection was 47.5%. There were no differences between intervention groups in mean birthweight (3104 g vs. 3090 g P = 0.629) proportion of low birthweight (< 2500 g; 8.1% vs. 8.7% P = 0.755) or maternal anaemia in the third trimester [33.0% (158/479) vs. 32.3% (152/471) P = 0.815]. However the proportion of very low birthweight (< 1500 g) was significantly lower in the mebendazole group [0% (0/479) vs. 1.5% (7/471) P = 0.007]. This trial provides additional evidence for the use of anthelmintics over and above iron supplementation within antenatal care programmes in hookworm-endemic areas. Benefits of de-worming may be higher in countries not having an antenatal iron supplementation programme or where intensity of hookworm infections is higher. (authors) |
| Databáze: | OpenAIRE |
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