Characteristics of bilateral versus unilateral temporal encephalocele-associated epilepsy
| Autor: | Laurent M. Willems, Philipp S. Reif, Thomas M. Freiman, Felix Rosenow, Adam Strzelczyk, Marlies Wagner, Esther Paule, Johann Philipp Zöllner |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Drug Resistant Epilepsy Early detection Temporal lobe Temporal encephalocele 03 medical and health sciences Epilepsy Young Adult 0302 clinical medicine Germany Medicine Humans Epilepsy surgery In patient Aged Encephalocele Retrospective Studies Aged 80 and over business.industry Treatment options Retrospective cohort study Electroencephalography General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Neurology Epilepsy Temporal Lobe Anticonvulsants Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Seizure. 71 |
| ISSN: | 1532-2688 |
| Popis: | Purpose To characterise bilateral temporal encephalocele (BTE)-associated epilepsy relative to unilateral temporal encephalocele (UTE)-associated epilepsy as a rare but curable cause of structural epilepsy using demographics, epilepsy status and imaging findings. Method In this single-centre retrospective study we included all patients from June 2015 to August 2018, who suffered from epilepsy and were diagnosed with a temporal encephalocele. Data were systematically collected and analysed for differences between BTE and UTE. Results Seventeen epilepsy patients diagnosed with temporal encephaloceles (TE) were identified. One-third exhibited BTE. The age of epilepsy onset was higher in patients with BTE compared to UTE (median 51 vs. 37 years, p = 0.074). Latency between epilepsy diagnosis and definitive TE diagnosis differed considerably with a median five-fold shorter duration for the BTE-group when compared to the UTE-group (2–10 years, p = 0.02). Five of seven (81%) patients with BTE were pharmacoresistant, while this applied to only five out of ten (50%) patients with a UTE. Conclusion When compared to UTE-associated epilepsy, BTE-associated epilepsy is characterised by a later age at onset, shorter delay in TE diagnosis and more frequent drug-resistance. As epilepsy surgery is a valid treatment option for both syndromes, a standardised diagnostic workup should be implemented for temporal lobe epilepsy (TLE) patients with unknown aetiology to facilitate early detection of UTE and BTE. |
| Databáze: | OpenAIRE |
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