Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population
| Autor: | Eng-Zhuan Ban, Pei Pei Chong, Yoke-Yeow Yap, Munn-Sann Lye, Chin-Chye Lim, Shaneeta Visuvanathan |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Xeroderma pigmentosum Genotype Science Nasopharyngeal neoplasm Biology Polymorphism Single Nucleotide Asian People Gene Frequency Risk Factors Odds Ratio medicine Humans Allele frequency Alleles Aged Xeroderma Pigmentosum Group D Protein Genetics Multidisciplinary Carcinoma Homozygote Malaysia Nasopharyngeal Neoplasms Odds ratio Middle Aged medicine.disease Nasopharyngeal carcinoma Case-Control Studies Transcription factor II H Medicine Female Research Article Nucleotide excision repair |
| Zdroj: | PLoS ONE, Vol 10, Iss 6, p e0130530 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The xeroderma pigmentosum group D (XPD) gene encodes a DNA helicase, an important component in transcription factor IIH (TFIIH) complex. XPD helicase plays a pivotal role in unwinding DNA at the damaged region during nucleotide excision repair (NER) mechanism. Dysfunctional XPD helicase protein from polymorphic diversity may contribute to increased risk of developing cancers. This study aims to determine the association between XPD K751Q polymorphism (rs13181) and risk of nasopharyngeal carcinoma (NPC) in the Malaysian population. In this hospital-based matched case-control study, 356 controls were matched by age, gender and ethnicity to 356 cases. RFLP-PCR was used to genotype the XPD K751Q polymorphism. A significant association was observed between XPD K751Q polymorphism and the risk of NPC using conditional logistic regression. Subjects with homozygous Lys/Lys (wildtype) genotype have 1.58 times higher odds of developing NPC compared to subjects with recessive combination of heterozygous Lys/Gln and homozygous Gln/Gln genotypes (OR = 1.58, 95% CI = 1.05–2.38 p = 0.028) adjusted for cigarette smoking, alcohol and salted fish consumption. Our data suggests that Lys/Lys (wildtype) of XPD K751Q contributes to increased risk of NPC in the Malaysian population. |
| Databáze: | OpenAIRE |
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