Bioevaluation of 32P patch designed for the treatment of skin diseases
| Autor: | Mónica A. Palmieri, Máximo Croci, Hebe Durán, Vanina Araceli Medina, R. Ughetti, Marcela Zubillaga, María J. Salgueiro, Rosana Pirchio, J.O. Nicolini |
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| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
Biodistribution Pathology medicine.medical_specialty Skin Neoplasms Metabolic Clearance Rate medicine.medical_treatment Brachytherapy Chromic phosphate Administration Cutaneous Mice chemistry.chemical_compound Silicone medicine Animals Tissue Distribution Radiology Nuclear Medicine and imaging business.industry Dose fractionation Dose-Response Relationship Radiation medicine.disease Disease Models Animal Dose–response relationship Treatment Outcome Open source chemistry Molecular Medicine Female Dose Fractionation Radiation Skin cancer Nuclear medicine business Phosphorus Radioisotopes |
| Zdroj: | Nuclear Medicine and Biology. 35:233-237 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/j.nucmedbio.2007.08.004 |
| Popis: | Objective The objective of this study was to design and evaluate a 32 P patch for the treatment of skin diseases. Materials and Methods The patch was prepared from chromic phosphate 32 P and silicone. Bioelimination and biodistribution in healthy and treated animals, and the therapeutic efficacy of two treatment schemes (single dose and fractionated dose) in an animal model of skin cancer were studied. Results Based on the bioelimination and biodistribution studies, no leakage of 32 P from the patch was observed. The treated tumors reduced their mean diameter compared to controls. The single-dose therapeutic scheme showed a higher number of complete and partial remissions compared to the fractionated scheme. These results were confirmed by histopathological analysis of the samples. Conclusion The 32 P patch was designed and produced according to specifications for the treatment of superficial lesions of the skin. Although the 32 P patch is an open source, it behaves like a sealed one for use in brachytherapy treatments. |
| Databáze: | OpenAIRE |
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