Purine transport by Malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster

Autor: David T. Sullivan, L A Bell, Marie C. Sullivan, D R Paton
Rok vydání: 1979
Předmět:
Zdroj: Biochemical Genetics. 17:565-573
ISSN: 1573-4927
0006-2928
DOI: 10.1007/bf00498891
Popis: Uptakes of guanine into Malpighian tubules of wild-type Drosophila and the eye color mutants white (w), brown (bw), and pink-peach (pp) have been compared. Tubules for each of these mutants are unable to concentrate guanine intracellularly. The transport of xanthine and riboflavin is also deficient in w tubules. The transport of guanosine, adenine, hypoxanthine, and guanosine monophosphate is similar in wild-type and white Malpighian tubules. These data and other information about these mutants make it likely that these pteridine-deficient eye color mutants do not produce pigments because of the inability to transport a pteridine precursor. This view supports the hypothesis that mutants which lack both pteridine and ommochromes do so because precursors to both classes of pigments share a common transport system.
Databáze: OpenAIRE