The role of the intestinal microflora in the reductive metabolism of acenocoumarol in man
| Autor: | L G Baars, H H Thijssen, A E Van den Bogaard, M.J. Hazen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1984 |
| Předmět: |
Pharmacology
Male Acenocoumarol Chemistry Metabolite Capsules Urine Absorption (skin) Intestines chemistry.chemical_compound Reductive metabolism Biochemistry Intestinal Absorption medicine Oral anticoagulant Humans Pharmacology (medical) Oxidation-Reduction Biotransformation medicine.drug Research Article |
| Popis: | Although the oral anticoagulant acenocoumarol (AC) is very effectively metabolized by the intestinal microflora to its amino metabolite, under clinical conditions this route of AC-disposition is of no importance because the compound is rapidly absorbed from its pharmaceutical application form. Only when the gastro-intestinal absorption is retarded, for instance by using a capsule as vehiculum, are appreciable amounts of reduced metabolites recovered in urine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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