Resiniferatoxin promotes adult worm expulsion in Trichinella spiralis-infected rats by Th2 immune response modulation
| Autor: | María Alejandra Moreno-García, José Luis Muñoz-Carrillo, Juan Francisco Contreras-Cordero, Oscar Gutiérrez-Coronado, José Jesús Muñoz-Escobedo, Claudia Maldonado-Tapia |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
030231 tropical medicine Immunology Trichinella spiralis Resiniferatoxin Th2 cytokines Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Th2 Cells medicine Parasite hosting Eosinophilia Animals Immunity Interleukin Trichinellosis biology.organism_classification Small intestine Rats 030104 developmental biology medicine.anatomical_structure chemistry Cytokines Parasitology medicine.symptom Diterpenes |
| Zdroj: | Parasite immunologyREFERENCES. 43(8) |
| ISSN: | 1365-3024 |
| Popis: | Background The immune response during T. spiralis infection is characterized by an increase in eosinophils and mast cells, as well as Th2 cytokine production, such as interleukin (IL)-4, IL-10, and IL-13, promoting T. spiralis expulsion from the host. However, this response damages the host, favoring the parasite survival. In the search for new pharmacological strategies that protect against T. spiralis infection, a recent study showed that treatment with resiniferatoxin (RTX) modulates the Th1 cytokines production, reducing muscle parasite burden. Objective To evaluate the effect of RTX treatment on the Th2 cytokines production, the number of eosinophils, mast cells, as well as the intestinal expulsion of T. spiralis. Methods Serum levels of IL-4, IL-10 and IL-13 were quantified by ELISA; the number of eosinophils, mast cells and the adult worms of T. spiralis in the small intestine were quantified. Results RTX treatment increased serum levels of IL-4, IL-10, and IL-13, and it decrease intestinal eosinophilia, however, favors the mastocytosis, promoting T. spiralis intestinal expulsion. Conclusions These findings suggest that RTX is capable to modulate the Th2 immune response, promoting T. spiralis expulsion, which contributes to the defense against T. spiralis infection, placing the RTX as a potential immunomodulatory drug. |
| Databáze: | OpenAIRE |
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