Evaluation and comparison of the efficacy of long-acting betamethasone and dexamethasone as injections in the treatment of idiopathic sudden hearing loss
| Autor: | Reza Erfanian, Shima Hajbegloo, Ardavan Tajdini, Hakima Abdullah, Nasrin Yazdani |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Poor prognosis Time Factors medicine.drug_class Hearing Loss Sensorineural Betamethasone Dexamethasone 03 medical and health sciences 0302 clinical medicine Hearing Humans Medicine 030223 otorhinolaryngology Glucocorticoids Injection Intratympanic medicine.diagnostic_test business.industry Hearing Loss Sudden Middle Aged Sudden Hearing Loss Treatment Outcome Long acting Otorhinolaryngology Hearing level Delayed-Action Preparations 030220 oncology & carcinogenesis Anesthesia Speech Perception Corticosteroid Female Audiometry business Follow-Up Studies medicine.drug |
| Zdroj: | American Journal of Otolaryngology. 42:102955 |
| ISSN: | 0196-0709 |
| DOI: | 10.1016/j.amjoto.2021.102955 |
| Popis: | Introduction & objective The aim of the present study was to determine the efficacy of long-acting betamethasone, and its comparison with Dexamethasone as an intratympanic injection in the treatment of Sudden Sensorineural Hearing Loss (SSNHL). Materials and methods Thirty-one patients who do not respond to systemic steroids and poor prognosis patients were enrolled in this study. The patients divided randomly into two groups: 1- Dexamethasone and 2- Long acting betamethasone. Dexamethasone (0.4 ml/mg) or long-acting betamethasone (0.1 ml/mg) was slowly injected (0.4 to 0.6 cc) into the superior-anterior area of the tympanic membrane as 6 injections twice a week for a total of 3 weeks. Right after the treatment and one, two and six months after completion of treatment, an audiometry was performed and compared with the pre-injection values. Results Speech Reception Threshold (SRT) showed improvements in both groups immediately after treatment and in the follow-up period, compared to baseline. Speech Discrimination Score (SDS) also improved in both groups directly after treatment and at one-month follow-up. The hearing improvement in the Dexamethasone group was clinically better than in the Beta group, but due to the non-parametric data, it was not possible to analyze the hearing improvement process in the variable group. Conclusion According to the results obtained in this study, intratympanic corticosteroid injection in the treatment of patients with SSNHL has positive and promising results on improving hearing level. |
| Databáze: | OpenAIRE |
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