Effects of chlorhexidine solution on neutrophil locomotion in vitro
| Autor: | Ian E. Addison, T.L.P. Watts, Beryl Johnson |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Analysis of Variance Lysis Dose-Response Relationship Drug Neutrophils Chlorhexidine Direct response Chemokinesis Chemotaxis Middle Aged Pharmacology Biology In vitro Peripheral blood Microbiology Chemotaxis Leukocyte Cell Movement Direct test medicine Humans General Dentistry medicine.drug |
| Zdroj: | Journal of Dentistry. 17:287-289 |
| ISSN: | 0300-5712 |
| DOI: | 10.1016/0300-5712(89)90041-9 |
| Popis: | The aim of this study was to ascertain the effect of low concentrations of chlorhexidine on the locomotor behaviour of neutrophils. A special feature was the use of a direct test of chemotaxis. Neutrophils recovered from peripheral blood of healthy adult volunteers were tested for chemokinesis and chemotaxis in the presence of chlorhexidine. A moderate dose-related direct response was observed in respect of both these parameters. It was also apparent that increasing concentrations of the drug inhibited a greater proportion of cells, so that there was total immobility at 0·2 per cent and many cells appeared lysed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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