Molecular evolution of the meiotic recombination pathway in mammals
| Autor: | Amy L. Dapper, Bret A. Payseur |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine Crossover Biology 010603 evolutionary biology 01 natural sciences Article 03 medical and health sciences Species Specificity Molecular evolution Genetics Animals Strand invasion Ecology Evolution Behavior and Systematics Phylogeny Mammals Recombination Genetic Phylogenetic tree Adaptation Physiological Synaptonemal complex Meiosis 030104 developmental biology Evolutionary biology Rate of evolution General Agricultural and Biological Sciences Homologous recombination Recombination |
| Zdroj: | Evolution; international journal of organic evolution. 73(12) |
| ISSN: | 1558-5646 |
| Popis: | Meiotic recombination shapes evolution and helps to ensure proper chromosome segregation in most species that reproduce sexually. Recombination itself evolves, with species showing considerable divergence in the rate of crossing-over. However, the genetic basis of this divergence is poorly understood. Recombination events are produced via a complicated, but increasingly well-described, cellular pathway. We apply a phylogenetic comparative approach to a carefully selected panel of genes involved in the processes leading to crossovers-spanning double-strand break formation, strand invasion, the crossover/non-crossover decision, and resolution-to reconstruct the evolution of the recombination pathway in eutherian mammals and identify components of the pathway likely to contribute to divergence between species. Eleven recombination genes, predominantly involved in the stabilization of homologous pairing and the crossover/non-crossover decision, show evidence of rapid evolution and positive selection across mammals. We highlight TEX11 and associated genes involved in the synaptonemal complex and the early stages of the crossover/non-crossover decision as candidates for the evolution of recombination rate. Evolutionary comparisons to MLH1 count, a surrogate for the number of crossovers, reveal a positive correlation between genome-wide recombination rate and the rate of evolution at TEX11 across the mammalian phylogeny. Our results illustrate the power of viewing the evolution of recombination from a pathway perspective. |
| Databáze: | OpenAIRE |
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