Relation between serum triglyceride level, serum urate concentration, and fractional urate excretion
Autor: | Alessandro Giacomello, C. P. Quaratino, Nicola Di Sciascio |
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Rok vydání: | 1997 |
Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Urine Excretion chemistry.chemical_compound Endocrinology Internal medicine Blood plasma medicine Humans Triglycerides Aged Creatinine Triglyceride Osmolar Concentration Middle Aged medicine.disease Uric Acid Serum urate Menopause Postmenopause Cross-Sectional Studies chemistry Premenopause Uric acid Female |
Zdroj: | Metabolism: clinical and experimental. 46(9) |
ISSN: | 0026-0495 |
Popis: | The relations between serum urate levels and age, serum cholesterol, creatinine, glucose, and triglyceride concentrations were studied in 930 men and 298 premenopausal and 478 postmenopausal women, taking into account the renal handling of uric acid. All subjects were outpatients, and statistical evaluation was performed on cases corresponding to the central 95th percentile of the biochemical variables measured. An alternative analysis excluding subjects with serum glucose or creatinine levels outside the normal range was also performed. In men, premenopausal and postmenopausal women, and their normoglycemic normocreatininemic subsets, serum triglyceride level was positively correlated with serum urate concentration and inversely correlated with fractional urate excretion in both simple and multiple linear regression analysis. In men and postmenopausal women, there was also a strong positive independent association between serum urate and creatinine levels. This association was significant also in the normoglycemic normocreatininemic subset of men, but it was insignificant in normoglycemic normocreatininemic postmenopausal women. In this large cross-sectional study, a negative correlation between serum triglyceride concentration and renal uric acid excretion has been demonstrated. |
Databáze: | OpenAIRE |
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