The first silicon(IV) phthalocyanine-nucleoside conjugates with high photodynamic activity
| Autor: | Xiu-Rong Huang, Bi-Yuan Zheng, Lei Wang, Xiao-Min Shen, Jian-Dong Huang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Silicon
Indoles Stereochemistry medicine.medical_treatment Photodynamic therapy Apoptosis Conjugated system Isoindoles Inorganic Chemistry chemistry.chemical_compound Coordination Complexes Neoplasms medicine Humans Photosensitizer Microscopy Confocal Photosensitizing Agents Cytidine Nucleosides Hep G2 Cells Combinatorial chemistry Uridine chemistry Photochemotherapy Phthalocyanine Nucleoside |
| Zdroj: | Dalton transactions (Cambridge, England : 2003). 42(29) |
| ISSN: | 1477-9234 |
| Popis: | A series of novel silicon(IV) phthalocyanines conjugated axially with different nucleoside moieties (uridine, 5-methyluridine, cytidine, and 5-N-cytidine derivatives) have been synthesized and evaluated for their photodynamic activities. The uridine-containing compound 1 exhibits the highest photocytotoxicity against HepG2 human hepatocarcinoma cells with an IC50 value as low as 6 nM, which can be attributed to its high cellular uptake and non-aggregated nature in the biological media. This compound shows high affinity toward the mitochondria of HepG2 cells and causes cell death mainly through apoptosis upon illumination. The result indicates that 1 is a highly promising photosensitizer for photodynamic therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|