The Fat Content of Small Primary Breast Cancer Interferes with Radiofrequency-Induced Thermal Ablation
| Autor: | George Tzovaras, Despina O. Sioutopoulou, Evangelos Athanassiou, Nikolaos C. Vamvakopoulos, M. Sakellariou, Constantinos Hatzitheofilou, F. Karasavvidou, E. Tziastoudi |
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| Rok vydání: | 2008 |
| Předmět: |
Ablation Techniques
Adult Pathology medicine.medical_specialty business.industry Fat content Thermal ablation Breast Neoplasms Middle Aged Prognosis Radiofrequency Therapy medicine.disease Tumor ablation Breast cancer Adipose Tissue Image Processing Computer-Assisted medicine Humans Female Surgery Radiology business Primary breast cancer Software Aged |
| Zdroj: | European Surgical Research. 42:54-58 |
| ISSN: | 1421-9921 0014-312X |
| DOI: | 10.1159/000168318 |
| Popis: | Background: Radiofrequency (RF) thermal ablation is a minimally invasive technique of local mass elimination with variable efficiency. Methods: Ten patients with small primary breast cancer diagnosed preoperatively by core needle biopsy were ablated percutaneously by an RF (Radionics Cool-tip) device operating on impedance control mode. The percent fat-containing area was calculated in each slide of a total of 47 slides introduced to IQ materials software image analysis. Results: Seven of 10 tumors with tumor diameter less than 2.8 cm and fat content less than 12.47% were totally ablated (score 3). One of 10 with 3 cm tumor diameter and 5.45% fat content showed an intermediate degree of ablated tissue (score 2), and the last 2 with 2 cm and 2.2 cm tumor diameter and more than 19.74% tumor fat content were minimally ablated (score 1). Our present exploratory study on 10 patients suggests dependence of the degree of thermal damage on tumor fat content. Conclusions: We conclude that the fat content of small primary breast cancer could serve as a ‘heat sink’ and should be considered as a preventing factor of complete local tumor destruction by RF thermal ablation. |
| Databáze: | OpenAIRE |
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