Predictive value of peritoneal cancer index for survival in patients with mucinous peritoneal malignancies treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a single centre experience
| Autor: | Moritz von Winterfeld, Wieland Raue, Beate Rau, Andreas Brandl, Matthilde Feist, Sascha Weiss, Johann Pratschke, Alexander Krannich |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Physiology Colorectal cancer 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine medicine Humans In patient Peritoneal Neoplasms Retrospective Studies business.industry fungi Cancer Cytoreduction Surgical Procedures Hyperthermia Induced Middle Aged medicine.disease Adenocarcinoma Mucinous Survival Analysis Predictive value 030220 oncology & carcinogenesis Conventional PCI Peritoneal Cancer Index Female 030211 gastroenterology & hepatology Hyperthermic intraperitoneal chemotherapy Cytoreductive surgery business |
| Zdroj: | International Journal of Hyperthermia. 34:512-517 |
| ISSN: | 1464-5157 0265-6736 |
| Popis: | This study investigated the correlation between the peritoneal carcinomatosis index (PCI) and patient outcome depending on the tumour type.Peritoneal surface malignancy (PSM) treatment depends on tumour type. Mucinous PSM (m-PSM) is associated with a better prognosis than non-mucinous PSM (nm-PSM). The PCI's predictive ability has not yet been evaluated.We analysed 123 patients with PSM treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) between 2008 and 2015. The m-PSM group (n = 75) included patients with appendiceal cancer (n = 15), colorectal cancer (n = 21), or low-grade appendiceal mucinous neoplasm (n = 39); the nm-PSM group (n = 48) included patients with gastric (n = 18) or colorectal (n = 30) cancer. The PCI's predictive ability was evaluated by multiple Cox-proportional hazard regression analysis and Kaplan-Meier curves.The 5-year survival and PCI were higher in m-PSM patients (67.0%; 20.5 ± 12.1) than in nm-PSM patients (32.6%; p = 0.013; 8.9 ± 6.0; p 0.001). Colorectal nm-PSM patients with PCI ≥16 had a worse 2-year survival (25.0%) vs. patients with PCI16 (79.1%; log rank = 0.009), but no significant effect was observed in patients with m-PSM (66.7% vs. 68.1%; p = 0.935). Underlying disease (HR 5.666-16.240), BMI (HR 1.109), and PCI (HR 1.068) significantly influenced overall survival in all patients.PCI is prognostic in nm-PSM, but not in m-PSM. CRS and HIPEC may benefit not only patients with low PCI, but also those with high PCI and m-PSM. |
| Databáze: | OpenAIRE |
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