Phosphonolipids as non-viral vectors for gene therapy
| Autor: | Jean-Jacques Yaouanc, J.‐C. Clement, Herve Des Abbayes, Christine Gable-Guillaume, Gwénaëlle Le Bolc’h, Nathalie Le Bris, Claude Ferec, Virginie Floch |
|---|---|
| Přispěvatelé: | Chimie, Electrochimie Moléculaires et Chimie Analytique (CEMCA), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Génétique moléculaire et génétique épidémiologique, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Transfer DNA
Genetic enhancement 01 natural sciences Ammoniums Viral vector 03 medical and health sciences chemistry.chemical_compound Drug Discovery Polyamines [CHIM]Chemical Sciences Non-vital transfection 030304 developmental biology Pharmacology 0303 health sciences 010405 organic chemistry Chemistry Organic Chemistry Genetic transfer General Medicine In vitro 0104 chemical sciences Biochemistry Cell culture Phosphonolipids DNA K562 cells |
| Zdroj: | European Journal of Medicinal Chemistry European Journal of Medicinal Chemistry, Elsevier, 1998, 33, pp.923--934. ⟨10.1016/S0223-5234(99)80017-8⟩ |
| ISSN: | 0223-5234 1768-3254 |
| DOI: | 10.1016/S0223-5234(99)80017-8⟩ |
| Popis: | International audience; Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoietic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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