Supplemental Figure Legends 1-5 from TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors

Autor: Charles G. Drake, Drew M. Pardoll, Thomas W. Dubensky, Sarah M. McWhirter, Meredith L. Leong, Andrew B. Sharabi, Ariel E. Marciscano, Laura Hix Glickman, Gabrielle L. Reiner, Kelsey E. Sivick, Debebe Theodros, Anthony L. Desbien, Ali Ghasemzadeh, Brian J. Francica
Rok vydání: 2023
Popis: S1: Timeline of necrosis after CDN injection. S2: CDN injection causes a distinct cytokine and cellular profile in the tumor draining lymph nodes. S3: B16F10 is not directly killed by CDN exposure and behaves similarly to other mouse and human cell lines. S4: TNFα blockade reduces necrosis after IT CDN. S5: Outgrowth and CDN treatment of B16F10 is effected in selected knockout animals.
Databáze: OpenAIRE