Copeptin predicts 10-year all-cause mortality in community patients: a 10-year prospective cohort study
| Autor: | Heiner C. Bucher, Jonas Odermatt, Manuel Ottiger, Beat Mueller, Philipp Schuetz, Rebekka Bolliger, Lara Hersberger, Mirjam Christ-Crain, Matthias Briel |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Clinical Biochemistry Population 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Copeptin Risk Factors Internal medicine Post-hoc analysis medicine Humans Prospective Studies Prospective cohort study education Respiratory Tract Infections education.field_of_study Proportional hazards model business.industry Biochemistry (medical) Hazard ratio Glycopeptides Respiratory infection 030208 emergency & critical care medicine Retrospective cohort study General Medicine Middle Aged Prognosis Survival Rate ROC Curve Female business Biomarkers Follow-Up Studies |
| ISSN: | 2016-0151 |
| Popis: | Background: Copeptin, the C-terminal part of the arginine vasopressin (AVP) precursor peptide, is secreted in response to stress and correlates with adverse clinical outcomes in the acute-care hospital setting. There are no comprehensive data regarding its prognostic value in the community. We evaluated associations of copeptin levels with 10-year mortality in patients visiting their general practitioner (GP) for a respiratory infection included in a previous trial. Methods: This is a post hoc analysis including data from 359 patients included in the PARTI trial. Copeptin was measured in batch-analysis on admission and after 7 days. We calculated Cox regression models and area under the receiver operating characteristic curve (AUC) to assess an association of copeptin with mortality and adverse outcome. Follow-up data were collected by GP, patient and relative tracing through phone interviews 10 years after trial inclusion. Results: After a median follow-up of 10.0 years, mortality was 9.8%. Median admission copeptin levels (pmol/L) were significantly elevated in non-survivors compared to survivors (13.8, IQR 5.9–27.8; vs. 6.3 IQR 4.1–11.5; p Conclusions: In a sample of community-dwelling patients visiting their GP for a respiratory infection, copeptin levels were associated with 10-year all-cause mortality. In conjunction with traditional risk factors, this marker may help to better direct preventive measures in this population. |
| Databáze: | OpenAIRE |
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