Hyperthyroidism affects arterial stiffness, plasma NT‐pro‐B‐type natriuretic peptide levels, and subendocardial perfusion in patients with Graves' disease
| Autor: | Robert Pichler, Walter Brandstätter, Hatzl-Griesenhofer M, Georg Biesenbach, W. Maschek, Gerd Bodlaj, Jörg Berg |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Adolescent endocrine system diseases medicine.drug_class Graves' disease Hyperthyroidism Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Aged Triiodothyronine business.industry Arteries General Medicine Middle Aged Aortic Augmentation Index medicine.disease Brain natriuretic peptide Elasticity Graves Disease Peptide Fragments Thyroxine Endocrinology medicine.anatomical_structure Arterial stiffness Female business Perfusion hormones hormone substitutes and hormone antagonists Artery |
| Zdroj: | Annals of Medicine. 39:608-616 |
| ISSN: | 1365-2060 0785-3890 |
| Popis: | Arterial stiffness is thought to play a critical role in the pathogenesis of cardiovascular events, and in hyperthyroidism increased cardiovascular event rates have been reported.To investigate markers of systemic arterial stiffness, volume homeostasis, and subendocardial perfusion and its interrelationship in patients with Graves' disease (GD) in hyperthyroidism and euthyroidism.Aortic augmentation index (AIx@75) as a measure of systemic arterial stiffness and subendocardial viability ratio (SEVR) as a surrogate measure of subendocardial perfusion were assessed by applanation tonometry in 59 patients with GD in hyperthyroidism and euthyroidism, and measurements were compared to plasma levels of NT-pro-B-type natriuretic peptide (NT-ProBNP).AIx@75 and NT-ProBNP levels were significantly increased in hyperthyroidism compared to euthyroidism and were positively correlated with each other. SEVR was significantly decreased in hyperthyroidism compared to euthyroidism, mainly due to increased heart rates as shown by the heart rate-corrected SEVR75.In hyperthyroidism, patients with GD exhibited increased systemic arterial stiffness, paralleled by increased levels of NT-ProBNP, a marker of volume overload. The decreased subendocardial perfusion in hyperthyroidism seemed to be mainly due to increased heart rates. The observed unfavorable hemodynamic alterations in hyperthyroidism may serve to explain increased cardiovascular event rates in patients with GD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|