Increased GFAP and S100beta but not NSE serum levels after subarachnoid haemorrhage are associated with clinical severity

Autor: C. Zimmerman, M. Van Gils, Tjemme Beems, Pieter E. Vos, M. M. Verbeek
Rok vydání: 2006
Předmět:
Adult
Male
medicine.medical_specialty
Pathology
Subarachnoid hemorrhage
Enolase
Statistics as Topic
Glasgow Outcome Scale
Brain damage
S100 Calcium Binding Protein beta Subunit
macromolecular substances
Neuroinformatics [DCN 3]
Gastroenterology
Severity of Illness Index
Aneurysm
Cognitive neurosciences [UMCN 3.2]
Internal medicine
Severity of illness
Glial Fibrillary Acidic Protein
medicine
Perception and Action [DCN 1]
Neurosensory disorders [UMCN 3.3]
Humans
Nerve Growth Factors
cardiovascular diseases
Alzheimer Centre [NCEBP 11]
Aged
Aged
80 and over
Glial fibrillary acidic protein
biology
business.industry
S100 Proteins
Middle Aged
Subarachnoid Hemorrhage
medicine.disease
Neurology
Genetic defects of metabolism [UMCN 5.1]
nervous system
Phosphopyruvate Hydratase
biology.protein
Subarachnoid haemorrhage
Female
Neurology (clinical)
Microbial pathogenesis and host defense [UMCN 4.1]
medicine.symptom
business
Zdroj: European Journal of Neurology, 13, 632-8
European Journal of Neurology, 13, 6, pp. 632-8
ISSN: 1351-5101
Popis: Contains fulltext : 50908.pdf (Publisher’s version ) (Closed access) Assessment of initial disease severity after subarachnoid haemorrhage (SAH) remains difficult. The objective of the study is to identify biochemical markers of brain damage in peripheral blood after SAH. Hospital admission S100beta, glial fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE) serum levels were analysed in 67 patients with SAH. Disease severity was determined by using the World Federation of Neurological Surgeons (WFNS) scale and the Fisher CT (computerized tomography) grading scale. Mean astroglial serum concentrations taken at hospital admission were increased (S100beta 2.8-fold and GFAP 1.8-fold) compared with the upper limit of normal laboratory reference values (P95). The mean NSE concentration was within normal limits. S100beta (P < 0.001) and GFAP (P =0.011) but not NSE levels were higher in patients who were in coma at the time of hospital admission compared with patients who were not. Similarly S100beta and GFAP but not NSE serum levels increased with higher WFNS scores, raised intracranial pressure and higher CT Fisher grade scores. Concerning the location of the aneurysm, S100beta and GFAP serum levels were within normal limits after a perimesencephalic type of haemorrhage and significantly increased after aneurysmal type SAH. Increased glial (S100beta and GFAP) but not neuronal (NSE) protein serum concentrations are found after SAH, associated to the clinical severity of the initial injury.
Databáze: OpenAIRE
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