Expression and localization of bone morphogenetic proteins (BMPs) and BMP receptors in ossification of the ligamentum flavum

Autor: Yasuhiro Ishidou, Hiroki Yoshida, N. Origuchi, Kyouji Hayashi, Takeshi Imamura, K. Yonemori, T. K. Sampath, P. ten Dijke, T. Nagamine, Mitsuyasu Kato, Shingo Maeda, Takashi Sakou
Rok vydání: 1997
Předmět:
Adult
Male
musculoskeletal diseases
Pathology
medicine.medical_specialty
Histology
Physiology
Activin Receptors
Bone Morphogenetic Protein 7
Endocrinology
Diabetes and Metabolism
Bone Morphogenetic Protein 2
Receptors
Cell Surface
Bone Morphogenetic Protein 4
Cartilage metabolism
Protein Serine-Threonine Kinases
Bone morphogenetic protein
Bone morphogenetic protein 2
Radioligand Assay
Transforming Growth Factor beta
medicine
Humans
Receptors
Growth Factor
Bone morphogenetic protein receptor
Endochondral ossification
Aged
Cell Size
Ossification
business.industry
Calcinosis
Bone Morphogenetic Protein Receptors
Middle Aged
musculoskeletal system
Immunohistochemistry
Bone morphogenetic protein 7
Cartilage
Ligamentum Flavum
Bone morphogenetic protein 4
Bone Morphogenetic Proteins
Female
medicine.symptom
business
Zdroj: Bone. 21:23-30
ISSN: 8756-3282
DOI: 10.1016/s8756-3282(97)00080-x
Popis: To clarify the pathogenesis of ossification of the ligamentum flavum (OLF), we examined the expression and localization of bone morphogenetic proteins (BMPs) and their receptors (BMPRs) in the ligamentum flavum of the patients with OLF by immunohistochemical staining and compared them with staining patterns in control patients. The BMPRs appeared extensively in mature and immature chondrocytes around the calcified zone and in spindle-shaped cells and round cells in the remote part from ossified foci in examined tissue of OLF. The ligands for BMPRs, BMP-2/-4 and osteogenic protein-1 (OP-1)/BMP-7, colocalized in OLF patients. In the control cases, expression of BMPs and BMPRs was observed around the calcified zone at the insertion of the ligamentum flavum to the bone, and limited expression was found in the smaller range. Thus, the expression profile of BMPs and BMPRs in OLF patients was entirely different from the control patients, suggesting that BMPs may be involved in promoting endochondral ossification at ectopic ossification sites in OLF, and that ossification activity is continuous in these patients.
Databáze: OpenAIRE
Externí odkaz: