Localization of c-MYB in differentiated cells during postnatal molar and alveolar bone development
| Autor: | Lucia Knopfová, Vlasta Lungová, Eva Matalová, Jan Šmarda, Marcela Buchtová, Eva Janečková, Abigail S. Tucker |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty animal structures Cementoblast Cellular differentiation Genes myc Biology Mice Proto-Oncogene Proteins c-myb 03 medical and health sciences 0302 clinical medicine Alveolar Process Ameloblasts In Situ Nick-End Labeling medicine Animals MYB General Dentistry Connective Tissue Cells 030304 developmental biology Dental Cementum Regulation of gene expression 0303 health sciences Bone Development Gene Expression Regulation Developmental Cell Differentiation Molar Cell biology Odontoblast 030220 oncology & carcinogenesis Odontogenesis Dental cementum Ameloblast |
| Zdroj: | European Journal of Oral Sciences. 120:495-504 |
| ISSN: | 0909-8836 |
| Popis: | The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation. In this study, the pattern of expression of c-MYB was followed during postnatal stages of mouse molar odontogenesis using immunohistochemistry on serial sections. Along with an abundance of the c-MYB protein in proliferating zones, we confirmed the presence of this protein in differentiated ameloblasts, odontoblasts, and osteoblasts. In addition, c-MYB was also found in cementoblasts and alveolar fibroblasts. These findings suggest integration of c-MYB into regulatory networks during hard-tissue differentiation and mineralization. |
| Databáze: | OpenAIRE |
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