A randomised controlled trial of peri-operative pregabalin vs. placebo for video-assisted thoracoscopic surgery
| Autor: | L. Y. H. Mok, Alex Konstantatos, Matthew T. V. Chan, William Howard, David A Story, D. Boyd |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Pregabalin Placebo Preoperative care law.invention Placebos 03 medical and health sciences 0302 clinical medicine Randomized controlled trial 030202 anesthesiology law Preoperative Care medicine Humans Postoperative Care Analgesics Pain Postoperative Morphine Thoracic Surgery Video-Assisted business.industry Chronic pain Perioperative Middle Aged medicine.disease Surgery Analgesics Opioid Anesthesiology and Pain Medicine Cardiothoracic surgery Anesthesia Video-assisted thoracoscopic surgery Quality of Life Female business 030217 neurology & neurosurgery Follow-Up Studies medicine.drug |
| Zdroj: | Anaesthesia. 71:192-197 |
| ISSN: | 0003-2409 |
| Popis: | We allocated 52 participants to oral pregabalin 300 mg and 48 participants to placebo tablets before thoracoscopic surgery and for five postoperative days. The median (IQR [range]) cumulative pain scores at rest for nine postoperative months were 184 (94-274 [51-1454]) after pregabalin and 166 (66-266 [48-1628]) after placebo, p = 0.39. The corresponding scores on deep breathing were 468 (281-655 [87-2870]) and 347 (133-561 [52-3666]), respectively, p = 0.16. After three postoperative months, 29/100 participants had persistent surgical site pain, 19/52 after pregabalin and 10/48 after placebo, p = 0.12, of whom four and five, respectively, attended a pain management clinic, p = 0.24. The median (IQR [range]) morphine equivalent consumption six days after surgery was 273 (128-619 [39-2243]) mg after pregabalin and 319 (190-663 [47-2258]) mg after placebo, p = 0.35. |
| Databáze: | OpenAIRE |
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