Primary Type3 (Non-ABC, Non-GCB) Subtype of Extranodal Diffuse Large B-Cell Lymphoma of the Thyroid Bearing No MYD88 Mutation by Padlock Probe Hybridization
| Autor: | Yasuhiko Todo, Riko Kitazawa, Ayaka Ouchi, Hiroaki Miyaoka, Sohei Kitazawa, Yukiko Nishi, Yasuo Ueda, Yuri Kamaoka, Ryuma Haraguchi, Ken Yamamoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Case Report Biology medicine.disease_cause Primary extranodal malignant lymphoma lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine Missense mutation Neoplastic transformation Mutation Thyroid MYD88 gene mutation Diffuse large B-cell lymphoma MYD88 Gene Mutation medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lymphoma 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Immunohistochemistry |
| Zdroj: | Case Reports in Oncology, Vol 10, Iss 2, Pp 508-514 (2017) Case Reports in Oncology |
| ISSN: | 1662-6575 |
| Popis: | Primary extranodal malignant lymphoma of the thyroid is a rare entity composed of mostly neoplastic transformation of germinal center-like B cells (GCB) or memory B cells. Other B-cell-type malignancies arising primarily in the thyroid have rarely been described. Immunohistochemical examination of autopsied primary malignant lymphoma of the thyroid in an 83-year-old Japanese female revealed the presence of a non-GCB subtype of diffuse large B-cell lymphoma (DLBCL) without the typical codon 206 or 265 missense mutation of MYD88. The lack of the highly oncogenic MYD88 gene mutation, frequently observed in DLBCL of the activated B-cell (ABC) subtype, and the detection of an extremely aggressive yet local clinical phenotype demonstrated that the present case was an exceptional entity of the type3 (non-GCB and non-ABC) subtype. |
| Databáze: | OpenAIRE |
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