Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen: Comparison of acrylic and sol-gel approaches
| Autor: | Porkodi Kadhirvel, Fernando Silva, Manuel Azenha, Paula Gomes, Sudhirkumar Shinde, Boerje Sellergren, Eric Schillinger |
|---|---|
| Přispěvatelé: | Faculdade de Ciências |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Naproxen
Magnetic Resonance Spectroscopy Kinetics 02 engineering and technology 01 natural sciences Biochemistry Dissociation (chemistry) Analytical Chemistry Molecular Imprinting chemistry.chemical_compound Chemical sciences [Natural sciences] medicine Sol-gel Química [Ciências exactas e naturais] Chromatography 010401 analytical chemistry Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Solid Phase Extraction Molecularly imprinted polymer Imidazoles General Medicine Química 021001 nanoscience & nanotechnology 0104 chemical sciences Monomer chemistry Acrylates Chemical sciences Thermodynamics 0210 nano-technology Molecular imprinting Selectivity Gels medicine.drug |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | a b s t r a c t Imidazolium-based monomers were, for the first time, employed in a comprehensive investigation of the molecular imprinting process of naproxen in both acrylic and sol-gel tridimensional networks. To this end, molecularly imprinted polymer (MIP) and xerogel (MIX) were both optimized for performance, by testing different porogen, template speciation and component ratios. The developed imprints were characterized for their pore properties (nitrogen adsorption analysis), site heterogeneity, binding prop- erties and other performance parameters such as the imprinting factor, selectivity (HPLC column tests), column efficiency and mass transfer kinetics (frontal analysis study). MIP exhibited mesoporosity (Dp 29 nm), whereas MIX did not, which was reflected in both the lower number of accessible imprinted sites (4.9 mol/g versus 3.7 mol/g) and the slower binding/dissociation in MIX. The naproxen/ibuprofen selectivity ratio was estimated as 6.2 for the MIX and 2.5 for the MIP. Given the high importance of capac- ity and fast mass transfer in typical applications of imprinted materials, and the satisfactory selectivity of MIP, it can be concluded that the acrylic approach was globally the most advantageous. Still, the remark- ably high selectivity of MIX and its reasonable capacity demonstrate that future work devoted to further optimization of both formats is worthwhile. |
| Databáze: | OpenAIRE |
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